Relationship between hypoxia inducible factor-1α and esophageal squamous cell carcinoma: a meta analysis / 中华病理学杂志
Chinese Journal of Pathology
;
(12): 593-599, 2014.
Article
Dans Chinois
| WPRIM
| ID: wpr-304442
ABSTRACT
<p><b>OBJECTIVE</b>To explore the expression of hypoxia inducible factor-1α(HIF-1α) in esophageal squamous cell carcinoma and its correlation with clinicopathological features.</p><p><b>METHODS</b>Original literatures in foreign languages regarding correlation between HIF-1α and esophageal squamous cell carcinoma were identified from Cochrane Library, PubMed, EMbase database, and Chinese original literatures were from CBM, CNKI. All analyses were performed by Stata 11.0 software. Histological grade, degree of differentiation, T stage, lymph node metastasis, tumor stage, lymphatic invasion and vascular invasion were analyzed using pooled odds ratio (OR) with 95% confidence interval (CI).</p><p><b>RESULTS</b>A total of 14 studies including 1 121 patients were enrolled in this meta analysis. Comparing with normal tissue, the expression of HIF-1α in esophageal squamous cell carcinoma was significantly enhanced (OR = 0.088, 95% CI 0.061-0.129, P = 0.000); HIF-1α was significantly associated with T stage and lymph node metastasis (OR = 0.421, 95% CI 0.222-0.798, P = 0.008; OR = 0.387, 95% CI 0.207-0.725, P = 0.003). High expression of HIF-1α was correlated with an increased depth of tumor invasion, more lymph node metastasis and advanced tumor stage, whereas there was no relation to the degree of differentiation, histological grade, tumor stage, lymphatic invasion and vascular invasion.</p><p><b>CONCLUSIONS</b>High expression of HIF-1α protein correlates with an increased risk of esophageal squamous cell carcinoma. HIF-1α may be an indicator for T stage, lymph node metastasis and tumor stage, but further studies are needed.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Anatomopathologie
/
Tumeurs de l'oesophage
/
Carcinome épidermoïde
/
Marqueurs biologiques tumoraux
/
Intervalles de confiance
/
Odds ratio
/
Sous-unité alpha du facteur-1 induit par l'hypoxie
/
Métastase lymphatique
/
Métabolisme
Type d'étude:
Etude d'étiologie
/
Étude pronostique
/
Revues systématiques évaluées
Limites du sujet:
Humains
langue:
Chinois
Texte intégral:
Chinese Journal of Pathology
Année:
2014
Type:
Article
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