Plant-specific type III polyketide synthases superfamily: crystal structures and functions / 生物工程学报
Chinese Journal of Biotechnology
;
(12): 1-14, 2012.
Article
Dans Chinois
| WPRIM
| ID: wpr-304518
ABSTRACT
Plant type III polyketide synthase (PKS) generates backbones of a variety of plant secondary metabolites with diverse functions, and has long been models to elucidate the relationship between the three-dimensional structure and function. More than 80 type IIII PKS crystal structures with different functions have been reported in Protein Data Bank, including the crystal structures of the well-studied Chalcone Synthase of plant type III PKS, as well as the 6 other kinds of PKSs in the family, which are critical for understanding the structural basis for diverse starter molecule selectivity, polyketide chain length and the cyclization reaction. Structure-based analysis and site-directed mutagenesis are foundation for the investigation of enzyme engineering, genetic and metabolic engineering. This review summarized 7 plant-specific type III PKS in the aspects of their crystal structures and functions.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Physiologie
/
Protéines végétales
/
Plantes
/
Spécificité du substrat
/
Acyltransferases
/
Données de séquences moléculaires
/
Catalyse
/
Génie génétique
/
Chimie
/
Séquence d'acides aminés
langue:
Chinois
Texte intégral:
Chinese Journal of Biotechnology
Année:
2012
Type:
Article
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