Relationship of MTHFR gene polymorphisms with infertility / 中华男科学杂志
National Journal of Andrology
;
(12): 171-174, 2016.
Article
Dans Chinois
| WPRIM
| ID: wpr-304731
ABSTRACT
The folate metabolic pathway plays important roles in cellular physiology by participating in nucleotide synthesis, DNA repair and methylation, and maintenance and stability of the genome. Methylenetetrahydrofolate reductase (MTHFR) is a key regulatory enzyme involved in folate metabolism. Polymorphisms of MTHFR may change the level of homocysteine and affect DNA synthesis and methylation, leading to an increased oxidative stress and disturbed methylation reactions and consequently affecting reproductive function. This article presents an overview on MTHFR gene polymorphisms, proposing that multicentered, large-sample and long-term prospective studies are needed to reveal the relationship between MTHFR gene polymorphisms and infertility.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Polymorphisme génétique
/
ADN
/
Études prospectives
/
Méthylation de l'ADN
/
Methylenetetrahydrofolate reductase (NADPH2)
/
Réparation de l'ADN
/
Acide folique
/
Génétique
/
Homocystéine
/
Infertilité
Type d'étude:
Étude observationnelle
Limites du sujet:
Humains
langue:
Chinois
Texte intégral:
National Journal of Andrology
Année:
2016
Type:
Article
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