Effects of prostaglandin E1 on the progression of aristolochic acid nephropathy / 中国医学科学杂志(英文版)
Chinese Medical Sciences Journal
;
(4): 67-69, 2005.
Article
Dans Anglais
| WPRIM
| ID: wpr-305456
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effects of prostaglandin E1 (PGE1) on the progression of aristolochic acid nephropathy (AAN).</p><p><b>METHODS</b>Twenty-four patients diagnosed as AAN with serum creatinine (Scr) between 1.5 mg/dL and 4 mg/dL during September 2001 to August 2003 were randomly divided into 2 groups. All patients had ingested long dan xie gan wan containing aristolochic acid (0.219 mg/g) for at least 3 months. Twelve patients were injected with Alprostadil (10 microg/d for 10 days in one month, summing up to 6 months). Except for PGE1, the other therapy was same in both groups. Renal function was assessed using reciprocal serum creatinine levels (1/Scr).</p><p><b>RESULTS</b>The level of Scr an d serum hemoglobin (Hgb) was similar in both groups prior to therapy. During follow-up, 1/Scr levels in PGE1 group were significantly higher than control group (P < 0.01), and Hgb levels in PGE1 group were significantly increased compared with control (P < 0.05).</p><p><b>CONCLUSION</b>PGE1 can slow the progression of renal failure and increase Hgb level of AAN patient.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Anatomopathologie
/
Sang
/
Hémoglobines
/
Alprostadil
/
Études de suivi
/
Créatinine
/
Acides aristolochiques
/
Utilisations thérapeutiques
/
Traitement médicamenteux
/
Rein
Type d'étude:
Étude observationnelle
/
Étude pronostique
Limites du sujet:
Adulte
/
Femelle
/
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Chinese Medical Sciences Journal
Année:
2005
Type:
Article
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