Effect of 2-phenoxyethanol on potency of Sabin inactivated poliomyelitis vaccine and its safety / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology
; (6): 44-46, 2007.
Article
Dans Zh
| WPRIM
| ID: wpr-305500
Responsable en Bibliothèque :
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect of 2-phenoxyethanol on potency of Sabin inactivated poliomyelitis vaccine (IPV).</p><p><b>METHODS</b>Sabin IPV samples containing 5 mg or 7 mg 2-phenoxyethanol each dosage respectively were placed separately at 4 degrees C, 37 degrees C for 2 days and 7 days. D-antigen contents were tested with ELISA method. Then neutralizing antibodies in mice and guinea pigs were detected. The safety experiment was performed according to unusual toxicity test of China requirement for biological product.</p><p><b>RESULTS</b>After addition of 2-phenoxyethanol, the I, II, and III D-antigen contents of Sabin IPV did not change. The antibody levels in mice and guinea pigs were not different between experimental group and control group. Animals were safe during observation period.</p><p><b>CONCLUSION</b>2-Phenoxyethanol had no effect on potency and safety of Sabin IPV. It can be used as antiseptic for Sabin IPV.</p>
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Pharmacologie
/
Poids
/
Cellules Vero
/
Test ELISA
/
Tests de neutralisation
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Vaccin antipoliomyélitique inactivé
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Chlorocebus aethiops
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Stabilité de médicament
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Allergie et immunologie
/
Éthylène glycols
Limites du sujet:
Animals
langue:
Zh
Texte intégral:
Chinese Journal of Experimental and Clinical Virology
Année:
2007
Type:
Article