Relationship between vitamin D receptor gene Fok I polymorphisms and benign prostatic hyperplasia complicated by histological prostatitis / 中华男科学杂志
National Journal of Andrology
; (12): 880-883, 2011.
Article
de Zh
| WPRIM
| ID: wpr-305772
Bibliothèque responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the relationship between vitamin D receptor (VDR) gene Fok I polymorphisms and BPH complicated by histological prostatitis (BPH + HP).</p><p><b>METHODS</b>We detected Fok I polymorphisms in the peripheral blood of 79 patients with BPH + HP and 81 controls with BPH only using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), and analyzed the frequency distribution of the genotypes and alleles of the two groups of patients.</p><p><b>RESULTS</b>Obvious differences were found in the distribution of genotypes and alleles between the BPH + HP patients (FF: 27% [21/79], Ff: 30% [24/79], ff: 43% [34/79]) and the controls (FF: 33% [27/81], Ff: 36% [29/81], ff: 31% [25/81]), with statistical significance in the distribution of the genotype ff (P < 0.05). The histological prostatitis group showed a significant difference from the controls in the frequency of the f allele (58% [196/338] vs 49% [153/312], P < 0.05), but not in that of the F allele (42% [142/338] vs 51% [159/312] , P > 0.05).</p><p><b>CONCLUSION</b>VDR Fok I polymorphisms may be correlated with BPH complicated by histological prostatitis.</p>
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Hyperplasie de la prostate
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Prostatite
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Études cas-témoins
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Réaction de polymérisation en chaîne
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Récepteur calcitriol
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Prédisposition génétique à une maladie
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Polymorphisme de nucléotide simple
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Allèles
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Fréquence d'allèle
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Génétique
Type d'étude:
Observational_studies
Limites du sujet:
Aged
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Humans
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Male
langue:
Zh
Texte intégral:
National Journal of Andrology
Année:
2011
Type:
Article