Relationship between vitamin D receptor gene Fok I polymorphisms and benign prostatic hyperplasia complicated by histological prostatitis / 中华男科学杂志
National Journal of Andrology
;
(12): 880-883, 2011.
Article
Dans Chinois
| WPRIM
| ID: wpr-305772
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the relationship between vitamin D receptor (VDR) gene Fok I polymorphisms and BPH complicated by histological prostatitis (BPH + HP).</p><p><b>METHODS</b>We detected Fok I polymorphisms in the peripheral blood of 79 patients with BPH + HP and 81 controls with BPH only using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), and analyzed the frequency distribution of the genotypes and alleles of the two groups of patients.</p><p><b>RESULTS</b>Obvious differences were found in the distribution of genotypes and alleles between the BPH + HP patients (FF 27% [21/79], Ff 30% [24/79], ff 43% [34/79]) and the controls (FF 33% [27/81], Ff 36% [29/81], ff 31% [25/81]), with statistical significance in the distribution of the genotype ff (P < 0.05). The histological prostatitis group showed a significant difference from the controls in the frequency of the f allele (58% [196/338] vs 49% [153/312], P < 0.05), but not in that of the F allele (42% [142/338] vs 51% [159/312] , P > 0.05).</p><p><b>CONCLUSION</b>VDR Fok I polymorphisms may be correlated with BPH complicated by histological prostatitis.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Hyperplasie de la prostate
/
Prostatite
/
Études cas-témoins
/
Réaction de polymérisation en chaîne
/
Récepteur calcitriol
/
Prédisposition génétique à une maladie
/
Polymorphisme de nucléotide simple
/
Allèles
/
Fréquence d'allèle
/
Génétique
Type d'étude:
Étude observationnelle
Limites du sujet:
Adulte très âgé
/
Humains
/
Mâle
langue:
Chinois
Texte intégral:
National Journal of Andrology
Année:
2011
Type:
Article
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