Y-chromosome microdeletions do not affect the outcomes of ICSI for infertile males / 中华男科学杂志
National Journal of Andrology
;
(12): 771-774, 2011.
Article
Dans Chinois
| WPRIM
| ID: wpr-305793
ABSTRACT
<p><b>OBJECTIVE</b>To compare the outcomes of intracytoplasmic sperm injection (ICSI) for infertile males with Y-chromosome microdeletions and for those with azoospermia or severe oligospermia but without Y-chromosome microdeletions.</p><p><b>METHODS</b>We retrospectively analyzed 56 cycles of ICSI for 48 infertile cases with Y microdeletions (Group A) and 94 cycles for 90 cases with azoospermia or severe oligospermia but without Y-chromosome microdeletions (Group B) during the same period. We compared the two groups in the females' age, duration of infertility, males' age, number of oocytes retrieved, number of ICSI oocytes, fertilization rate, good embryo rate, number of embryos transferred, implantation rate, clinical pregnancy rate, abortion rate, live birth rate and babies' sexes.</p><p><b>RESULTS</b>There were no significant differences between Groups A and B in the females' age, duration of infertility, males' age, number of oocytes retrieved, number of ICSI oocytes and number of embryos transferred (P > 0.05), nor in the rates of fertilization (69.0% vs 73.2%), good embryos (53.3% vs 48.7%), implantation (24.0% vs 30.3%), biochemical pregnancy (41.1% vs 44.7%), clinical pregnancy (37.5% vs 35.1%), early abortion (4.8% vs 6.1%) and live birth (35.7% vs 29.2%) (P > 0.05).</p><p><b>CONCLUSION</b>Y-chromosome microdeletions do not affect the outcomes of ICSI. The affected couples should be informed of the necessity of prenatal genetic diagnosis before embryo implantation and the inevitability of vertical transmission to male offspring.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Oligospermie
/
Aberrations des chromosomes sexuels
/
Thérapeutique
/
Études rétrospectives
/
Délétion de segment de chromosome
/
Résultat thérapeutique
/
Taux de grossesse
/
Injections intracytoplasmiques de spermatozoïdes
/
Chromosomes Y humains
/
Azoospermie
Type d'étude:
Étude observationnelle
Limites du sujet:
Adulte
/
Femelle
/
Humains
/
Mâle
/
Grossesse
langue:
Chinois
Texte intégral:
National Journal of Andrology
Année:
2011
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS