Effect of folic acid in preventing aberrant methylation of fetal endometriosis susceptibility gene HOXA10 / 南方医科大学学报
Journal of Southern Medical University
;
(12): 926-929, 2013.
Article
Dans Chinois
| WPRIM
| ID: wpr-306437
ABSTRACT
<p><b>OBJECTIVE</b>To detect aberrant methylation in the promoter region of fetal endometriosis susceptibility gene homeobox-10 (HOXA10) in women with and without folic acid supplementation and explore the effect of folic acid in optimizing intrauterine environment.</p><p><b>METHODS</b>Thirty-six cord blood specimens were collected between January, 2010 and December, 2012 from pregnant women with endometriosis, including 22 with folic acid treatment and 15 without. Methylation-specific polymerase chain reaction (MSP) and bisulfite salt modified sequencing (BSP) were employed to detect aberrant methylation of HOXA10 gene in these specimens.</p><p><b>RESULTS</b>The methylation rate of HOXA10 gene differed significantly between pregnant women with endometriosis taking folic acid and those who did (P<0.05).</p><p><b>CONCLUSION</b>Folic acid treatment can significantly reduce the methylation rate of fetal endometriosis susceptibility gene HOXA10.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Pharmacologie
/
Régions promotrices (génétique)
/
Protéines à homéodomaine
/
Méthylation de l'ADN
/
Utilisations thérapeutiques
/
Endométriose
/
Foetus
/
Acide folique
/
Génétique
/
Métabolisme
Limites du sujet:
Femelle
/
Humains
/
Grossesse
langue:
Chinois
Texte intégral:
Journal of Southern Medical University
Année:
2013
Type:
Article
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