Value of four serum markers in the diagnosis of rheumatoid arthritis / 南方医科大学学报
Journal of Southern Medical University
; (12): 538-541, 2013.
Article
de Zh
| WPRIM
| ID: wpr-306518
Bibliothèque responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To systematically evaluate the values of 4 serum markers in the diagnosis of rheumatoid arthritis (RA).</p><p><b>METHODS</b>Serum samples were obtained from 278 RA patients and 510 control subjects and the levels of rheumatoid factor (RF), anticyclic citrullinated peptide antibody (CCP), antikeratin antibody (AKA), and glucose-6-phosphate isomerase (GPI) were detected using immune turbidimetry, ELISA, indirect immunofluorescence, and ELISA, respectively. The values of these 4 serum markers and their combinations in RA diagnosis were systemically assessed.</p><p><b>RESULTS</b>In RA diagnosis using one serum marker, two markers, and three or four markers, RF, RF+CCP, RF+CCP+GPI, respectively, had the highest sensitivity; CCP, CCP+AKA, and RF+CCP+AKA+GPI, respectively, had the highest specificity; CCP, CCP+GPI, and RF+CCP+AKA+GPI, respectively, had the highest positive predictive value; GPI, RF+CCP, and RF+CCP+GPI, respectively, had the highest negative predictive value; CCP, CCP+GPI, and RF+CCP+AKA+GPI, respectively, had the highest positive likely ratio; GPI, RF+CCP, and RF+CCP+GPI, respectively, had the lowest negative likely ratio.</p><p><b>CONCLUSION</b>CCP, RF+CCP, and RF+CCP+GPI are the most ideal for RA diagnosis using one, two, and three or more markers, respectively. CCP is the essential marker for RA diagnosis, and a combined detection of the serum makers can significantly improve the diagnostic accuracy.</p>
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Polyarthrite rhumatoïde
/
Facteur rhumatoïde
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Autoanticorps
/
Sang
/
Marqueurs biologiques
/
Études cas-témoins
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Citrulline
/
Diagnostic
/
Allergie et immunologie
/
Glucose 6-phosphate isomerase
Type d'étude:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limites du sujet:
Adolescent
/
Adult
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Aged
/
Aged80
/
Female
/
Humans
/
Male
langue:
Zh
Texte intégral:
Journal of Southern Medical University
Année:
2013
Type:
Article