Potential of cell transplantation as an alternative to liver transplantation / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 405-409, 2011.
Article
Dans Chinois
| WPRIM
| ID: wpr-306550
ABSTRACT
Human hepatocyte transplantation to treat liver-based metabolic deficiencies and acute liver failure has shown promising early improvement in liver function; however, long-term success has not been achieved. Stem cell transplantation to restore liver function as an alternative to whole liver transplantation has not been successful in humans. As alternative sources of cells for human hepatocyte transplantation, stem cells are under investigation. The liver extracellular matrix presents an ideal scaffold for stem cell differentiation into hepatocytes, as well as cell transplantation. The innovative technique of the decellularized liver matrix presents great potential as the scaffold for hepatocyte maturation and transplantation, and allows the development of engineered recellularized liver graft for transplantation.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Chirurgie générale
/
Transplantation
/
Transplantation hépatique
/
Défaillance hépatique
/
Hépatocytes
/
Ingénierie tissulaire
/
Transplantation de cellules souches
/
Matrice extracellulaire
/
Structures d'échafaudage tissulaires
/
Régénération hépatique
Limites du sujet:
Humains
langue:
Chinois
Texte intégral:
Journal of Biomedical Engineering
Année:
2011
Type:
Article
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