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Study on relationship between TCM Syndrome types (Xin-qi and Xin-yang deficiency) and contents of cytokines (tumor necrosis factor-alpha and interleukins) in patients with congestive heart failure / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine ; (12): 876-878, 2004.
Article Dans Chinois | WPRIM | ID: wpr-306761
ABSTRACT
<p><b>OBJECTIVE</b>To explore the relationship between TCM Syndromes types, Xin-qi deficiency (XQD) and Xin-yang deficiency (XYD), and contents of cytokines, including tumor necrosis factor alpha (TNF-alpha), interleukin-6 (IL-6), IL-1beta and IL-10 in patients with congestive heart failure (CHF).</p><p><b>METHODS</b>Sixty-seven CHF in-patients with Xin-qi deficiency or Xin-yang deficiency syndrome were enrolled, their NYHA (New York Heart Association) cardiac function was assessed, ejection fraction (EF) and E peak/A peak (E/A) ratio were determined by Doppler ultrasonic echocardiograph, and serum TNF-alpha, II-6, IL-1beta and IL-10 were measured by double antibody sandwich ELISA assay.</p><p><b>RESULTS</b>The cardiac function grading in patients of XQD was mostly of I and II grade, while that in patients of XYD was mostly of III and IV grade (by Ridit analysis, P<0.01). The E/A and EF values were higher in patients of XQD than those in patients of XYD (P<0.01). Levels of TNF-alpha, IL-6 and IL-1beta were higher and IL-10 was lower in patients of XYD than those in patients of XQD (P<0.05 or P<0.01) respectively.</p><p><b>CONCLUSION</b>TNF-alpha, IL-6, IL-1beta and IL-10 probably play an important role in the development process of XQD to XYD, and could be taken as the microcosmic indexes for differentiation of the two syndromes.</p>
Sujets)
Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Physiologie / Débit systolique / Sang / Fonction ventriculaire gauche / Interleukine-6 / Interleukine-1 / Facteur de nécrose tumorale alpha / Déficit du Yin / Déficit du Yang / Interleukine-10 Type d'étude: Etude diagnostique Limites du sujet: Adulte très âgé / Aged80 / Femelle / Humains / Mâle langue: Chinois Texte intégral: Chinese Journal of Integrated Traditional and Western Medicine Année: 2004 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Physiologie / Débit systolique / Sang / Fonction ventriculaire gauche / Interleukine-6 / Interleukine-1 / Facteur de nécrose tumorale alpha / Déficit du Yin / Déficit du Yang / Interleukine-10 Type d'étude: Etude diagnostique Limites du sujet: Adulte très âgé / Aged80 / Femelle / Humains / Mâle langue: Chinois Texte intégral: Chinese Journal of Integrated Traditional and Western Medicine Année: 2004 Type: Article