Prevalence of abnormal glucose regulation in patients with chronic ischemic heart failure / 中华心血管病杂志

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the prevalence of diabetes mellitus (DM) and glucose abnormalities in patients with ischemic chronic heart failure (CHF).</p><p><b>METHODS</b>A total of 1004 hospitalized eligible patients from 52 hospitals in 7 Chinese cities were included in this study.</p><p><b>RESULTS</b>In this survey, 420 out of 1004 patients had DM history (41.8%), 175 patients were newly diagnosed as DM (17.4%), 208 patients (20.7%) had impaired glucose tolerance (IGT). NYHA grade increases in proportion to severity of abnormal glucose metabolism [(r(s)) = 0.17, P = 0.001]. After adjustment of age and other factors, logistic regression analyses showed risk of suffering severe CHF symptoms (NYHA III/IV) increases with the severity of abnormal glucose metabolism OR, 1.2, 95% CI 0.7 - 1.7 in patients with IGT; 1.4, 95% CI 0.9 - 2.1 in the newly diagnosed DM patients and 1.7, 95% CI 1.2 - 2.4 in the DM history group, respectively.</p><p><b>CONCLUSIONS</b>High prevalence of abnormal glucose metabolism was observed in patients with chronic ischemic hear failure and the severity of abnormal glucose metabolism was closely related to NYHA symptom grade.</p>