Studies on effect of microemulsion in enhancing solubility of baicalin and puerarin / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study the effect of O/W Microemulsion in enhancing solubility of baicalin and puerarin.</p><p><b>METHOD</b>The Pseudo-ternary phase diagram was employed to selected the formulations of O/W microemulsion. The partical size of microemulsion, and solubility of baicalin and puerarin in water, oil phase, surfactant, microemulsion and alcohol were determined, respectively.</p><p><b>RESULT</b>11 types of microemulsion formulations have the effect in enhancing the solubility of baicalin and puerarin; the solubility of Baicalin in microemulsion is higher as 5-15 times than it in water, the solubility of Puerarin in microemulsion is higher as 3 - 4 times than it in water.</p><p><b>CONCLUSION</b>Microemulsion is good in enhancing solubility of effective compounds extracted from Chinese medical herbs.</p>