Compatibility chemistry of acid-alkaline pair medicine of Dahuang and Huangbai in Dahuang Xiaoshi decoction / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To determine the change pattern of alkaline and acid components of Dahuang and Huangbai amoung different combinations in Dahuang Xiaoshi decotion.</p><p><b>METHOD</b>The contents of anthraquinones and berberine were determined by HPLC in samples of Dahuang extracts, Huangbai extracts, Dahuang and Huangbai pair medicine extracts, and extracts of whole recipe.</p><p><b>RESULT</b>The contents of anthraquinones and berberine were decreased with the changes of combinations from component medicinal material alone to pair medicines, and to whole recipe. the change pattern was more apparent in water decoctions than in ethanol extracts.</p><p><b>CONCLUSION</b>The contents of alkaline and acid components are changed with different extract methods and different combinations.</p>