p53 Expression in a Malignant Mesothelioma Patient during Seven-Year Follow-up / 결핵및호흡기질환
Tuberculosis and Respiratory Diseases
;
: 284-288, 2014.
Article
Dans Anglais
| WPRIM
| ID: wpr-30770
ABSTRACT
Malignant mesothelioma (MM) is the aggressive tumor of serosal surfaces. There are crude pathogenetic results regarding the biology of MM. Coordinated upregulations of p53 gene expression are shown in malignancies. We believed that there are changes in the p53 expression with transformation from reactive hyperplasia to MM. A 65-year-old male was admitted the hospital because of left pleuritic chest pains in 2004. Chest computed tomography (CT) results showed left pleural effusions with loculation and pleural thickening. Pathologic findings revealed reactive mesothelial hyperplasia. In 2008, the patient again felt left pleuritic chest pains. Chest CT showed progressive thickening of the left pleura. Pathologic diagnosis was atypical mesothelial hyperplasia. In 2011, chest CT showed progressive thickening of his left pleura. He was diagnosed with well-differentiated papillary mesothelioma. Serial change was analyzed by immunohistochemical staining for p53 of pleural tissues. There were no remarkable changes in p53 expressions during the transformation to MM.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Plèvre
/
Épanchement pleural
/
Thorax
/
Biologie
/
Douleur thoracique
/
Tomodensitométrie
/
Études de suivi
/
Gènes p53
/
Protéine p53 suppresseur de tumeur
/
Diagnostic
Type d'étude:
Etude diagnostique
/
Étude observationnelle
/
Étude pronostique
Limites du sujet:
Adulte très âgé
/
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Tuberculosis and Respiratory Diseases
Année:
2014
Type:
Article
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