Effect of granulocyte colony stimulating factor EPC on cardiac function in patients with heart failure after myocardial infarction / 南方医科大学学报
Journal of Southern Medical University
;
(12): 504-507, 2011.
Article
Dans Chinois
| WPRIM
| ID: wpr-307900
ABSTRACT
<p><b>OBJECTIVE</b>To study the changes of cardiac function following treatment with granulocyte colony stimulating factor (G-CSF) in patients with heart failure after myocardial infarction.</p><p><b>METHODS</b>Thirty-eight patients with heart failure after myocardial infarction were randomized into G-CSF treatment group and control group. All the patients received conventional treatment (medication and interventional therapy), and the patients in treatment group were given additional G-CSF (600 µg/day) for 7 consecutive days. The plasma level of brain-type natriuretic peptide (BNP) and the number of endothelial progenitor cells (EPCs) in the peripheral blood were detected before and at 7 days and 4 months after the treatment. The cardiac functions (LVSD, EDV, and LVEF) were evaluated by ultrasonic imaging before and at 2 weeks and 4 months after the treatment.</p><p><b>RESULTS</b>The number of EPCs was significantly higher in the treatment group than in the control group after the treatment especially at 7 days (P<0.01). In both groups, BNP level was lowered significantly after the treatment to recover the normal level (P<0.01). The cardiac functions were improved in all the patients at 7 days and 4 months after the treatment, and the improvement was more obvious in the treatment group (P<0.05), especially in terms of LVEF at 4 months after the treatment (P<0.01).</p><p><b>CONCLUSION</b>EPC mobilization by G-CSF can effectively improve the cardiac functions and lessen ventricular remodeling in patients with heart failure after myocardial infarction.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Thérapeutique
/
Facteur de stimulation des colonies de granulocytes
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Résultat thérapeutique
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Mobilisation de cellules souches hématopoïétiques
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Peptide natriurétique cérébral
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Remodelage ventriculaire
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Progéniteurs myéloïdes
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Biologie cellulaire
/
Cellules endothéliales
/
Utilisations thérapeutiques
Type d'étude:
Essai clinique contrôlé
Limites du sujet:
Adulte très âgé
/
Femelle
/
Humains
/
Mâle
langue:
Chinois
Texte intégral:
Journal of Southern Medical University
Année:
2011
Type:
Article
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