Linkage analysis of one family with autosomal dominant high myopia / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 424-426, 2008.
Article
de Zh
| WPRIM
| ID: wpr-308048
Bibliothèque responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To map the high myopia gene in a Chinese family with autosomal dominant high myopia.</p><p><b>METHODS</b>A family with autosomal dominant high myopia in three generations was collected. Eighteen short-tandem-repeat markers on previously reported loci linked to high myopia were chosen for genotyping and two-point linkage analysis was carried out.</p><p><b>RESULTS</b>The spherical equivalent of affected individuals ranges from -6.00D to -20.00D and the genetic pattern is autosomal dominant. The LOD score was less than -1 in all 18 microsatellite markers, indicating that there was no linkage between these markers and the high myopia related genes in this family.</p><p><b>CONCLUSION</b>A novel myopia locus for high-grade myopia may exist in the kindred. Genome-wide scan will be needed to determine this novel locus.</p>
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Pedigree
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Physiologie
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Réfraction oculaire
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Répétitions microsatellites
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Polymorphisme de nucléotide simple
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Génétique
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Liaison génétique
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Lod score
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Myopie
Limites du sujet:
Adolescent
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Adult
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Aged
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Aged80
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Female
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Humans
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Male
langue:
Zh
Texte intégral:
Chinese Journal of Medical Genetics
Année:
2008
Type:
Article