Effects of quercetin on morphology and VEGF secretion of leukemia cells NB4 in vitro / 中华肿瘤杂志
Chinese Journal of Oncology
;
(12): 25-27, 2006.
Article
Dans Chinois
| WPRIM
| ID: wpr-308430
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effects of quercetin on cell morphology and VEGF expression of acute myeloblastic leukemia cells NB4 in vitro.</p><p><b>METHODS</b>The cytomorphology of NB4 cells was assessed by Wright-stain, apoptosis rate by apoptotic marker Annexin V, and VEGF secretion level by ELISA.</p><p><b>RESULTS</b>Typical apoptosis was found in NB4 cells after treatment with quercetin. Apoptotic marker Annexin V analysis showed that the apoptotic rate of NB4 cells was increased after treatment with quercetin. The secretion of VEGF of NB4 cells was significantly decreased after treatment with quercetin.</p><p><b>CONCLUSION</b>Quercetin can induce apoptosis and inhibit secretion of VEGF in NB4 leukemia cells.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Anatomopathologie
/
Pharmacologie
/
Quercétine
/
Leucémie aigüe myéloïde
/
Apoptose
/
Sécrétions corporelles
/
Lignée cellulaire tumorale
/
Facteur de croissance endothéliale vasculaire de type A
/
Métabolisme
/
Antinéoplasiques d'origine végétale
Limites du sujet:
Humains
langue:
Chinois
Texte intégral:
Chinese Journal of Oncology
Année:
2006
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS