Risk factors for patent ductus arteriosus in neonates / 中国当代儿科杂志

ABSTRACT

<p><b>OBJECTIVE</b>To identify the risk factors for patent ductus arteriosus (PDA) in neonates.</p><p><b>METHODS</b>Fifty infants with PDA and 100 infants without PDA were enrolled. Chi-square test, Student's t test and the linear correlation analysis were used to study the clinical data. Logistic regression analysis was used to investigate the independent risk factors for PDA.</p><p><b>RESULTS</b>The prevalence of PDA was negatively correlated with the gestation age (r=-0.03, P<0.05) and birth weight (r=-0.04, P<0.05). Oxygen inhalation was a protective factor for the development of PDA. Fetal distress, meconium-stained amniotic fluid, oligohydramnios, cord entanglement, 1 minute Apgar score <8, maternal infection and hypoxic-ischemic encephalopathy were the independent risk factors for the development of PDA.</p><p><b>CONCLUSIONS</b>The incidence of PDA can be reduced by preventing maternal infection, premature birth, low birth weight and hypoxia.</p>