Lung adenoma development and NK activity in mice treated with multiple carcinogens
Journal of Korean Medical Science
;
: 1-5, 1992.
Article
Dans Anglais
| WPRIM
| ID: wpr-30961
ABSTRACT
A wide-spectrum initiation model was investigated in mice. Sequential treatments with diethylnitrosamine, urethane and N-methylnitrosourea, with or without a promoter, phenobarbital, resulted in tumor formation in the lungs in 85-90% of animals, but did not produce any tumorous lesions in other organs. The lung tumors were adenomas and the mean number of adenomas was 2.2-2.6 per mouse. Phenobarbital combination had no additive effect on lung tumor incidence and multiplicity. Splenic NK cell activity showed inconsistent increment in the carcinogen plus phenobarbital-treated group during the experiment (P less than 0.05).
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Phénobarbital
/
Uréthane
/
Cellules tueuses naturelles
/
Répartition aléatoire
/
Adénomes
/
N-Éthyl-N-nitroso-éthanamine
/
Tumeurs du poumon
/
1-Méthyl-1-nitroso-urée
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Journal of Korean Medical Science
Année:
1992
Type:
Article
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