Association of 8-hydroxyguanine glycosidase OGG1 Ser326Cys polymorphism with male infertility / 中华男科学杂志
National Journal of Andrology
;
(12): 518-522, 2014.
Article
Dans Chinois
| WPRIM
| ID: wpr-309680
ABSTRACT
<p><b>OBJECTIVE</b>To explore the association of 8-hydroxyguanine glycosidase OGG1 Ser326Cys polymorphism with semen quality and the risk of male infertility.</p><p><b>METHODS</b>This case-control study included 620 idiopathic infertile patients and 385 normal fertile controls. We determined their genotypes by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and analyzed their semen quality by computer-aided semen analysis (CASA).</p><p><b>RESULTS</b>The individuals with OGG1 326 Cys/Cys showed significantly lower sperm motility and concentration ([52.1 +/- 26.7]% and (3.75 +/- 0.91) x 10(6)/ml, ln transformed value) than the Ser/Ser carriers ([59.0 +/- 21.8] % and (4.12 +/- 0.88) x 10(6)/ml, ln transformed value) (P < 0.05). The risk of male infertility increased 69% in the OGG1 326Cys allele carriers as compared with the Ser carriers (OR = 1.69, 95% CI 1.24 -2.31).</p><p><b>CONCLUSION</b>OGG1 326 Ser/Cys polymorphism might contribute to the risk of male infertility in the southern Chinese population.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Études cas-témoins
/
Polymorphisme de nucléotide simple
/
DNA Glycosylases
/
Analyse du sperme
/
Génétique
/
Génotype
/
Infertilité masculine
Type d'étude:
Étude observationnelle
/
Facteurs de risque
Limites du sujet:
Adulte
/
Humains
/
Mâle
langue:
Chinois
Texte intégral:
National Journal of Andrology
Année:
2014
Type:
Article
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