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Mutation patterns in the RT region of hepatitis B virus P gene in patients treated with nucleoside/nucleotide analogs / 中华肝脏病杂志
Chinese Journal of Hepatology ; (12): 342-345, 2009.
Article Dans Chinois | WPRIM | ID: wpr-310090
ABSTRACT
<p><b>OBJECTIVE</b>To analyze mutation patterns in the RT region of hepatitis B virus (HBV) P gene in patients treated with nucleoside or nucleotide analogs.</p><p><b>METHODS</b>Viral DNA was extracted from 227 serum samples of chronic hepatitis B patients from September, 2005 to March, 2007. The RT region of HBV P gene was PCR-amplified and sequenced.</p><p><b>RESULTS</b>Known resistant mutations were found in 111 cases (48.9%) among 227 samples, 75 cases with clear therapy history. Novel mutations, including A222T, L229V and S256C, were also found. The incidence of multi-drug resistance in patients sequentially treated with lamivudine and adefovir was 25% (4/16), and none of the patients treated with lamivudine plus adefovir in combination shown multi-drug resistance.</p><p><b>CONCLUSION</b>The patterns of mutation is complex in nucleotide analogue treated patients. Switching to adefovir in lamivudine resistant patients may lead to multi-drug resistance. Novel mutations identified in this study need further investigation.</p>
Sujets)
Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Antiviraux / Pharmacologie / Variation génétique / Virologie / ADN viral / Analyse de mutations d&apos;ADN / Produits du gène pol / Virus de l&apos;hépatite B / Inhibiteurs de la transcriptase inverse / Hépatite B chronique Type d'étude: Étude pronostique Limites du sujet: Adolescent / Adulte / Adulte très âgé / Femelle / Humains / Mâle langue: Chinois Texte intégral: Chinese Journal of Hepatology Année: 2009 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Antiviraux / Pharmacologie / Variation génétique / Virologie / ADN viral / Analyse de mutations d&apos;ADN / Produits du gène pol / Virus de l&apos;hépatite B / Inhibiteurs de la transcriptase inverse / Hépatite B chronique Type d'étude: Étude pronostique Limites du sujet: Adolescent / Adulte / Adulte très âgé / Femelle / Humains / Mâle langue: Chinois Texte intégral: Chinese Journal of Hepatology Année: 2009 Type: Article