Mutation patterns in the RT region of hepatitis B virus P gene in patients treated with nucleoside/nucleotide analogs / 中华肝脏病杂志
Chinese Journal of Hepatology
;
(12): 342-345, 2009.
Article
Dans Chinois
| WPRIM
| ID: wpr-310090
ABSTRACT
<p><b>OBJECTIVE</b>To analyze mutation patterns in the RT region of hepatitis B virus (HBV) P gene in patients treated with nucleoside or nucleotide analogs.</p><p><b>METHODS</b>Viral DNA was extracted from 227 serum samples of chronic hepatitis B patients from September, 2005 to March, 2007. The RT region of HBV P gene was PCR-amplified and sequenced.</p><p><b>RESULTS</b>Known resistant mutations were found in 111 cases (48.9%) among 227 samples, 75 cases with clear therapy history. Novel mutations, including A222T, L229V and S256C, were also found. The incidence of multi-drug resistance in patients sequentially treated with lamivudine and adefovir was 25% (4/16), and none of the patients treated with lamivudine plus adefovir in combination shown multi-drug resistance.</p><p><b>CONCLUSION</b>The patterns of mutation is complex in nucleotide analogue treated patients. Switching to adefovir in lamivudine resistant patients may lead to multi-drug resistance. Novel mutations identified in this study need further investigation.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Antiviraux
/
Pharmacologie
/
Variation génétique
/
Virologie
/
ADN viral
/
Analyse de mutations d'ADN
/
Produits du gène pol
/
Virus de l'hépatite B
/
Inhibiteurs de la transcriptase inverse
/
Hépatite B chronique
Type d'étude:
Étude pronostique
Limites du sujet:
Adolescent
/
Adulte
/
Adulte très âgé
/
Femelle
/
Humains
/
Mâle
langue:
Chinois
Texte intégral:
Chinese Journal of Hepatology
Année:
2009
Type:
Article
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