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Cortical neuron apoptosis induced by beta-amyloid peptide and protective effect of panoxadiol in mice / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences ; (6): 451-455, 2008.
Article Dans Chinois | WPRIM | ID: wpr-310432
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the apoptosis of cortical neurons induced by beta-amyloid peptide (Abeta(1-40)) and the protective effect of panoxadiol.</p><p><b>METHODS</b>The Abeta(1-40) induced damage of primarily cultured mouse cortical neurons was examined with morphological observation, MTT assay, DNA agarose gel electrophoresis and Western-blot.</p><p><b>RESULT</b>After 48 h treated with 12 mumol/L Abeta(1-40), the cortical neurons showed apoptotic characteristics including decreased OD570 value in MTT assay, DNA cleavage fragment in electrophoresis and increased apoptotic cells. Western-blot showed that the expression of bcl-2 reduced significantly (P<0.05). Cell apoptosis was significantly attenuated in 40 mg/L panoxadiol treated group.</p><p><b>CONCLUSION</b>Panoxadiol can protect cultured cortical neurons from apoptosis induced by Abeta(1-40) in mice.</p>
Sujets)
Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Fragments peptidiques / Pharmacologie / Médicaments issus de plantes chinoises / Cellules cultivées / Cortex cérébral / Peptides bêta-amyloïdes / Apoptose / Neuroprotecteurs / Protéines proto-oncogènes c-bcl-2 / Biologie cellulaire Limites du sujet: Animaux / Grossesse langue: Chinois Texte intégral: Journal of Zhejiang University. Medical sciences Année: 2008 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Fragments peptidiques / Pharmacologie / Médicaments issus de plantes chinoises / Cellules cultivées / Cortex cérébral / Peptides bêta-amyloïdes / Apoptose / Neuroprotecteurs / Protéines proto-oncogènes c-bcl-2 / Biologie cellulaire Limites du sujet: Animaux / Grossesse langue: Chinois Texte intégral: Journal of Zhejiang University. Medical sciences Année: 2008 Type: Article