Changes in aortic endothelium ultrastructure in male rats following castration, replacement with testosterone and administration of 5alpha-reductase inhibitor / 亚洲男科学杂志(英文版)
Asian Journal of Andrology
;
(6): 843-847, 2007.
Article
Dans Anglais
| WPRIM
| ID: wpr-310443
ABSTRACT
<p><b>AIM</b>To investigate the relationship between low androgen level and ultrastructure of vascular endothelium.</p><p><b>METHODS</b>Forty-eight male Sprague-Dawley rats were randomly divided into four groups group A, normal rats with sham castration; group B, castrated rats; group C, castrated rats given testosterone (T) undecanoate; and group D, intact rats treated with 5alpha-reductase inhibitor. After 10 weeks of treatment or castration, rats in different groups were killed and serum T, free T (FT) and dihydrotestosterone (DHT) were measured. The aortic endothelia were scanned under electron microcopy and the Vascular Endothelium Structure Score (VESS) was computed.</p><p><b>RESULTS</b>Serum T and FT concentrations of rats in group B were significantly lower than those of the other three groups (P < 0.01); DHT concentrations of group D rats were significantly decreased (P < 0.01) when compared with those of groups A and C. Rats in groups B and D rats (with low androgen levels) had obvious damage to their endothelial surfaces, which appeared crimpled, rough, adhesive and ruptured, and had high destruction of VESS.</p><p><b>CONCLUSION</b>These results suggest that low concentrations of T and DHT are associated with ultrastructural damage of the aortic endothelia in male rats.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Aorte
/
Pharmacologie
/
5alpha-Dihydrotestostérone
/
Testostérone
/
Sang
/
Endothélium vasculaire
/
Orchidectomie
/
Rat Sprague-Dawley
/
Antienzymes
/
Inhibiteurs de la 5-alpha réductase
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Asian Journal of Andrology
Année:
2007
Type:
Article
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