Study on steroidal saponins from Dioscorea zingiberensis and their platelet aggregation activities / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 3782-3787, 2014.
Article
Dans Chinois
| WPRIM
| ID: wpr-310989
ABSTRACT
Using the absorbent resin, silica gel and ODS column chromatography as well as semi-preparative HPLC, ten compounds were isolated from 70% ethanol extract of tubers of Dioscorea zingiberensis C. H. Wright, and their structures were elucidated as trigoneoside XIIIa (1), parvifloside (2), trigoneoside IVa (3), deltoside (4), protobioside (5), lilioglycoside k (6), zingiberensis newsaponin I (7), deltonin (8), prosapogenin A of dioscin (9), and trillin (10) on the basis of NMR and MS spectral data analysis. Among these compounds, 1, 3, 5 and 6 were isolated from this plant for the first time. In the screening test on platelet aggregation, compounds 7 and 8 exhibited induction effect on platelet aggregation, while compound 9 exhibited significant inhibitory effect on platelet aggregation in vitro.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Pharmacologie
/
Saponines
/
Spectrométrie de masse
/
Médicaments issus de plantes chinoises
/
Structure moléculaire
/
Chimie
/
Agrégation plaquettaire
/
Rat Wistar
/
Dioscorea
Limites du sujet:
Animaux
langue:
Chinois
Texte intégral:
China Journal of Chinese Materia Medica
Année:
2014
Type:
Article
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