Polymorphism of Glutathione S-Transferases and Genetic Sensitivity of Childhood Acute Lymphoblastic Leukemia: A Meta-Analysis / 中国实验血液学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To analyze the relationship between GST polymorphism and childhood acute lymphoblastic leukemia(ALL) risk.</p><p><b>METHODS</b>The relevant references of this relationship in English or Chinese were extensively searched through PubMed, Embase, China National Knowledge Internet(CNKI) and Wanfang Database up to August 2015 based on the inclusion and exclusion criteria. GST polymorphism-specific odd ratios(OR) with corresponding 95% confidence intervals(CI) were calculated with the STATA statistical package. Heterogeneity across studies was assessed, and funnel plots were constructed to test the publication bias.</p><p><b>RESULTS</b>A total of 27 studies concerning the GST polymorphisms and the risk of ALL were evaluated, which included 3736 cases of childhood acute lymphoblastic leukemia and 5549 controls. Significant summary OR of ALL were obtained for GSTM1 (OR=1.41, 95% CI=1.21-1.65) and GSTT1 (OR=1.26, 95% CI=1.05-1.50). Subgroup analysis showed that GSTM1 variant was associated with increased susceptibility to ALL in group of Blacks, Asians, PB (Population-based controls), HB (Hospital-based controls) '≥ 100 cases' and '< 100 cases'. Regarding GSTT1 polymorphism, significant relation with ALL risk was found in subgroup of Asians, PB and '≥ 100 cases'.</p><p><b>CONCLUSION</b>The GSTM1 and GSTT1 polymorphisms may be cerrelated with an increased risk of ALL. Further investigations are needed to confirm the conclusions.</p>