A fiber optic chemical sensor system for on-line monitoring the drug dissolution of rifampicin / 药学学报

ABSTRACT

<p><b>AIM</b>To study a continuous, on-line and automatic monitoring method for dissolution of drugs.</p><p><b>METHODS</b>A new fiber optical chemical sensor prepared by sol-gel immobilization of molecular probe was reported. Based on multiple quenching of flurescence, an instrument and software system was designed to on-line monitor the drug dissolution of rifampicin.</p><p><b>RESULTS</b>The concentration of rifampicin was linear with ln(F0/F) when concentration was in the range of 10-170 micrograms/mL-1. The relative coefficient was 0.9993. The procession of dissolution can be on-line monitored. Parameters were obtained directly from the dissolution curve. There is no distinctly difference when compared with the method of the Pharmacopoeia of People's Republic of China (P > 0.05).</p><p><b>CONCLUSION</b>This procession analysis can reflect the real dissolution of drug and obtain the total information.</p>