Meta-analysis of efficacy and safety on neoadjuvant therapy for rectal cancer / 中华胃肠外科杂志
Chinese Journal of Gastrointestinal Surgery
;
(12): 1150-1155, 2012.
Article
Dans Chinois
| WPRIM
| ID: wpr-312329
ABSTRACT
<p><b>OBJECTIVE</b>To assess the value of neoadjuvant therapy for resectable rectal cancer and the impact on postoperative complications.</p><p><b>METHODS</b>Literature search was performed in PubMed, Ovid, Web of Science, Springer-Link and Elsevier ScienceDirect for randomized controlled trials published before May 2010 that compared neoadjuvant therapy with surgery alone or postoperative adjuvant therapy. The computer search was supplemented with hand search of reference lists for available primary studies. Inclusion criteria and quality assessment were performed.</p><p><b>RESULTS</b>Eleven studies including 7407 patients were enrolled for analysis. Neoadjuvant therapy group had significant advantages in local recurrence (OR=0.43, 95%CI0.37-0.50, P<0.01), distant recurrence (OR=0.85, 95%CI0.76-0.95, P<0.01), 5-year overall survival (RR=1.15, 95%CI1.04-1.28, P<0.01), and sphincter-saving surgery (RR=1.48, 95%CI1.17-1.87, P<0.01). There were no significant difference in postoperative mortality rate(OR=1.20, 95%CI0.68-2.13, P=0.53) and anastomotic complications (OR=1.04, 95%CI0.73-1.48, P=0.84).</p><p><b>CONCLUSION</b>Neoadjuvant therapy improves local control, distant recurrence and long-term survival without increasing postoperative complications.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Complications postopératoires
/
Tumeurs du rectum
/
Thérapeutique
/
Essais contrôlés randomisés comme sujet
/
Taux de survie
/
Traitement médicamenteux adjuvant
/
Radiothérapie adjuvante
/
Traitement néoadjuvant
/
Récidive tumorale locale
Type d'étude:
Essai clinique contrôlé
/
Revues systématiques évaluées
Limites du sujet:
Humains
langue:
Chinois
Texte intégral:
Chinese Journal of Gastrointestinal Surgery
Année:
2012
Type:
Article
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