Expression and clinical significance of Claudin-1 and Claudin-4 in colorectal cancer tissues / 中华胃肠外科杂志
Chinese Journal of Gastrointestinal Surgery
; (12): 1073-1076, 2012.
Article
de Zh
| WPRIM
| ID: wpr-312342
Bibliothèque responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of tight junction protein Claudin-1 and Claudin-4 in colorectal cancer tissues and its clinical significance.</p><p><b>METHODS</b>Immunohistochemical staining detected the expression of tight junction protein Claudin-1 and Claudin-4 in 60 cases of colorectal cancer and 20 normal colorectal mucosa tissue. The clinical significance was analyzed.</p><p><b>RESULTS</b>The positive rates of Claudin-1 and Claudin-4 in colorectal cancer tissues were 76.6%(46/60) and 85.0%(51/60), significantly higher than 20.0% (4/20) and 30.0%(6/20) in the normal colorectal mucosa(both P<0.01). The positive rates of Claudin-1 and Claudin-4 were associated with tumor differentiation degree, lymph node metastasis and TNM staging(all P<0.05).</p><p><b>CONCLUSIONS</b>The high expression of the Claudin-1 and Claudin-4 may play a promoting role in colorectal cancer development and progression. Claudin-1 and Claudin-4 may become prognostic markers of colorectal cancer.</p>
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Tumeurs colorectales
/
Chimie
/
Évolution de la maladie
/
Claudine-1
/
Claudine-4
/
Métastase lymphatique
/
Stadification tumorale
Limites du sujet:
Humans
langue:
Zh
Texte intégral:
Chinese Journal of Gastrointestinal Surgery
Année:
2012
Type:
Article