Antipyretic and anticonvulsant activity of n-hexane fraction of Viola betonicifolia
Asian Pacific Journal of Tropical Biomedicine
; (12): 280-283, 2013.
Article
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| ID: wpr-312415
Bibliothèque responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the antipyretic and anticonvulsant activities of n-hexane fraction of Viola betonicifolia (V. betonicifolia).</p><p><b>METHODS</b>The antipyretic effect was scrutinized using brewer's yeast induced pyrexia and anticonvlsion effect was tested using pentylenetetrazol and strychnine induced convulsion in mice.</p><p><b>RESULTS</b>N-hexane fraction of V. betonicifolia demonstrated highly significant antipyretic activity during various assessment times (1-5 h) when challenged in yeast induced pyrexia test. The effect was in a dose dependent manner with maximum attenuation (82.50%) observed at 300 mg/kg i.p. When tested in pentylenetetrazol induced convulsion test, the 1st stage (Ear and facial twitching) and 2nd stage (Convulsive wave through the body) was 100% protected during 24 h at all the test doses (300, 400 and 500 mg/kg i.p.), while the latency time of remaining stages was significantly increased. The maximum effect was observed by n-hexane fraction of V. betonicifolia at 400 and 500 mg/kg i.p., as the latency time for generalized clonic-tonic seizure (5th stage) was increased up to 25.34 min. However, n-hexane fraction of V. betonicifolia had no protection in strychnine induced convulsion test.</p><p><b>CONCLUSIONS</b>In conclusion, phytopharmacological studies provide scientific foundation to the folk uses of the plant in the treatment of pyrexia and neurological disorders.</p>
Mots clés
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Pharmacologie
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Crises épileptiques
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Extraits de plantes
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Chimie
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Viola
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Modèles animaux de maladie humaine
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Traitement médicamenteux
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Antipyrétiques
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Fièvre
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Hexanes
Limites du sujet:
Animals
langue:
En
Texte intégral:
Asian Pacific Journal of Tropical Biomedicine
Année:
2013
Type:
Article