Effects of cetylpyridinium chloride buccal tablets on halitosis induced by oral conditions / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1386-1389, 2014.
Article
Dans Chinois
| WPRIM
| ID: wpr-312565
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect of cetylpyridinium chloride buccal tablets on halitosis induced by oral conditions.</p><p><b>METHODS</b>With Porphyromonas gingivalis, Prevotella intermedia and Fusobacterium nucleatum as the testing bacteria, the minimal inhibitory concentration (MIC) of cetylpyridinium chloride buccal tablets was determined using minute amount serial dilution test. The production of volatile sulfur compounds (VSCs) was measured using sulfide detector halimeter in the anaerobic bacteria culture at 4 and 8 h after addition of the tablets. The effect of the tablets in suppressing odor production by mouth-borne halitosis bacteria was assessed using cysteine challenge test in healthy volunteers, and the effectiveness was evaluated by measuring the reduction in VSCs production and the duration of the effect.</p><p><b>RESULTS</b>Cetylpyridinium chloride buccal tablets inhibited the growth of all the 3 bacteria. The tablets obviously inhibited VSCs production by the 3 bacteria with a effect similar to chlorhexidine. Compared with distilled water gargle, the buccal tablets significantly reduced cysteine-induced VSCs production level in the healthy volunteers (P<0.05), and the effect lasted for 230 min.</p><p><b>CONCLUSION</b>Cetylpyridinium chloride tablets can obviously suppress bacteria responsible for oral halitosis and produce good effects in the treatment of halitosis induced by oral conditions.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Composés du soufre
/
Comprimés
/
Tests de sensibilité microbienne
/
Cétylpyridinium
/
Fusobacterium nucleatum
/
Porphyromonas gingivalis
/
Prevotella intermedia
/
Utilisations thérapeutiques
/
Traitement médicamenteux
/
Composés organiques volatils
Limites du sujet:
Humains
langue:
Chinois
Texte intégral:
Journal of Southern Medical University
Année:
2014
Type:
Article
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