Compound huangdai tablet as induction therapy for 193 patients with acute promyelocytic leukemia / 中华血液学杂志
Chinese Journal of Hematology
;
(12): 440-442, 2009.
Article
Dans Chinois
| WPRIM
| ID: wpr-314467
ABSTRACT
<p><b>OBJECTIVE</b>To report the results of curative and adverse effects of compound huangdai tablet (CHDT) as induction therapy for 193 patients with acute promyelocytic leukemia (APL).</p><p><b>METHODS</b>CHDT was administered 1.25 g orally three times a day after meal for three days, then the dosage was gradually increased to 7.5 g/d.</p><p><b>RESULTS</b>One hundred and ninety-three patients achieved complete remission (CR), 78.8% of whom in 30 to 60 days with an average time of 44.3 d. No serious infection, bleeding or DIC occurred during the treatment course. The major adverse effects were gastrointestinal symptoms. There was no change in lanine transaminase, urea, creatinine or electrocardiographic QTc interval in 110 APL patients observed before and after the treatment.</p><p><b>CONCLUSION</b>CHDT therapy is a modality of higher CR rate, good safety and tolerance without bone marrow suppression for APL patients.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Leucémie aiguë promyélocytaire
/
Études de suivi
/
Résultat thérapeutique
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Préparations à base de plantes
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Utilisations thérapeutiques
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Traitement médicamenteux
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Phytothérapie
Type d'étude:
Étude observationnelle
/
Étude pronostique
Limites du sujet:
Adolescent
/
Adulte
/
Adulte très âgé
/
Enfant
/
Enfant d'âge préscolaire
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Femelle
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Humains
/
Mâle
langue:
Chinois
Texte intégral:
Chinese Journal of Hematology
Année:
2009
Type:
Article
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