Prognostic factor analysis in 203 patients with chronic lymphocytic leukaemia / 中华血液学杂志
Chinese Journal of Hematology
; (12): 435-439, 2009.
Article
de Zh
| WPRIM
| ID: wpr-314468
Bibliothèque responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore prognostic factors in patients with chronic lymphocytic leukemia (CLL).</p><p><b>METHODS</b>Two hundred and three CLL patients in our hospital between 2000 to 2007 were retrospectively reviewed for prognostic factor analysis. Survival was analysed by Kaplan-Meier analysis, univariate analysis by Log-rank test and multivariate analysis by COX regression model.</p><p><b>RESULTS</b>With a median follow-up time of 48.0 (3.0-156.0) months, the 5-year overall survival (OS) rate was (87.3 +/- 2.4)% and 10-year OS rate was (77.4 +/- 3.3)%. Forty-eight (23.6%) patients died. Univariate analysis indicated that advanced clinical stage, B symptoms, extranodal involvement, number of lymph node regions involved > or = 3, enlarged liver, Hb < 100 g/L, BPC < 100 x 10(9)/L, absolute lymphocyte count (ALC) > 50 x 10(9)/L, atypical cell morphology, progression to stage, non-response to treatment, complicating infections and secondary cancer or disease transformation were associated with poor prognosis. And on multivariate analysis, lymph node region involved > or = 3 and atypical cell morphology were independent poor prognostic factors. Based on the two independent poor prognostic factors, three risk groups were defined: low--(0 factor), intermediate--(one factor) and high--(two factors) groups. The 5 year OS rates were (89.8 +/- 3.5)%, (66.4 +/- 7.2)% and (15.0 +/- 13.8)%, respectively, and the difference between them was statistically.</p><p><b>CONCLUSION</b>The number of lymph node region involved and cell morphology are useful for assessing CLL patients prognosis.</p>
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Anatomopathologie
/
Pronostic
/
Leucémie chronique lymphocytaire à cellules B
/
Modèles des risques proportionnels
/
Analyse multifactorielle
/
Études rétrospectives
/
Études de suivi
/
Estimation de Kaplan-Meier
/
Noeuds lymphatiques
Type d'étude:
Observational_studies
/
Prognostic_studies
Limites du sujet:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
langue:
Zh
Texte intégral:
Chinese Journal of Hematology
Année:
2009
Type:
Article