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The role of FDG-PET in staging of lymphoma and evaluation of therapeutic efficiency / 中华血液学杂志
Chinese Journal of Hematology ; (12): 233-236, 2009.
Article Dans Chinois | WPRIM | ID: wpr-314498
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the application of 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) to the staging and detecting residual masses of lymphoma.</p><p><b>METHODS</b>The clinical data of 179 patients with lymphoma were analyzed retrospectively. The results of FDG-PET, computed tomography (CT) and bone marrow biopsy (BMB) were compared for detection of lymph node/extranodal lymphoid tissue and bone marrow infiltration. Therapeutic efficiency was assessed by International Workshop Criteria (IWC) and Revised Integrated International Workshop Criteria (IWC + PET).</p><p><b>RESULTS</b>In the detection of 286 disease focuses in 98 patients before chemotherapy, the sensitivities of FDG-PET and CT were 73% and 70% (P < 0.01) in detecting nodal focus,and 87% and 45% (P < 0.01) in detecting extranodal lymphoma respectively. In detection of 104 lesions in 81 patients after chemotherapy,the sensitivities of FDG-PET and CT were 81% and 55% respectively (P < 0.01), and the specificities were 68% and 33%, respectively (P < 0.01) in detecting residual masses. According to IWC criteria, 33 patients achieved complete response/unconfirmed complete response (CR/CRu) , and 8 (24%) relapsed. Patients with PET-positive residual masses had a relapse rate of 40%, whereas only 21% of those with no such masses relapsed. Based on IWC + PET criteria, 25 patients achieved CR, with a relapse rate of 20%. Both FDG-PET and BMB produced positive results in 133/179 (74%) patients. Twenty-two patients with positive FDG-PET results were not detected by BMB. The sensitivities and specificities of FDG-PET for BM infiltration were 52% and 83%, respectively.</p><p><b>CONCLUSIONS</b>FDG-PET is a high sensitive and specific technique in staging and detecting residual masses of lymphoma.</p>
Sujets)
Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Anatomopathologie / Pronostic / Imagerie diagnostique / Études rétrospectives / Sensibilité et spécificité / Radiopharmaceutiques / Fluorodésoxyglucose F18 / Tomographie par émission de positons / Noeuds lymphatiques / Lymphomes Type d'étude: Etude diagnostique / Étude observationnelle / Étude pronostique Limites du sujet: Adolescent / Adulte / Adulte très âgé / Aged80 / Femelle / Humains / Mâle langue: Chinois Texte intégral: Chinese Journal of Hematology Année: 2009 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Anatomopathologie / Pronostic / Imagerie diagnostique / Études rétrospectives / Sensibilité et spécificité / Radiopharmaceutiques / Fluorodésoxyglucose F18 / Tomographie par émission de positons / Noeuds lymphatiques / Lymphomes Type d'étude: Etude diagnostique / Étude observationnelle / Étude pronostique Limites du sujet: Adolescent / Adulte / Adulte très âgé / Aged80 / Femelle / Humains / Mâle langue: Chinois Texte intégral: Chinese Journal of Hematology Année: 2009 Type: Article