Analysis of infection-related mortality after allogeneic hematopoietic stem cell transplantation in patients with refractory/relapse acute leukemia / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1377-1380, 2012.
Article
Dans Chinois
| WPRIM
| ID: wpr-315459
ABSTRACT
<p><b>OBJECTIVE</b>To investigate infection-related mortality (IRM) after allogeneic hematopoietic stem cell transplantation in patients with refractory/relapse acute leukemia.</p><p><b>METHODS</b>We conducted a retrospective analysis of 127 patients with refractory/relapse acute leukemia and investigated the incidence, causes and risk factors of IRM.</p><p><b>RESULTS</b>Sixty-seven of the patients died after the transplantation. The 5-year overall survival and disease-free survival was (35.2∓5.3)% and (30.8∓5.6)% among these patients, respectively. IRM occurred in 28.3% (36/127) of the patients. Multivariate analysis showed that grade II-IV acute graft-versus-host diseases (aGVDH, P=0.049, OR=3.017) and post-transplant invasive fungal infection (P=0.032, OR=3.223) were independent risk factors of IRM.</p><p><b>CONCLUSION</b>As a common cause of transplant-related mortality, IRM is more frequent in cases of refractory/relapse acute leukemia than in cases with a standard risk profile, and effective prophylaxis and treatment of severe GVHD remain currently the primary measures for reducing post-transplant IRM.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Anatomopathologie
/
Récidive
/
Chirurgie générale
/
Leucémies
/
Analyse multifactorielle
/
Études rétrospectives
/
Mortalité
/
Transplantation de cellules souches hématopoïétiques
/
Maladie du greffon contre l'hôte
/
Mycoses
Type d'étude:
Étude observationnelle
/
Étude pronostique
Limites du sujet:
Adolescent
/
Adulte
/
Femelle
/
Humains
/
Mâle
langue:
Chinois
Texte intégral:
Journal of Southern Medical University
Année:
2012
Type:
Article
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