Serum APPL1 level is elevated in newly diagnosed cases of type 2 diabetes mellitus / 南方医科大学学报
Journal of Southern Medical University
; (12): 1373-1376, 2012.
Article
de Zh
| WPRIM
| ID: wpr-315460
Bibliothèque responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate serum APPL1 level in patients with newly diagnosed type 2 diabetes mellitus (T2DM) and analyze its correlation with body mass index (BMI), waist-to-hip ratio (WHR), blood pressure, fasting plasma glucose, fasting blood insulin, HbA1c, and insulin resistance (HOMA-IR).</p><p><b>METHOD</b>Serum APPL1 levels were determined using ELISA in 22 normal control subjects and 63 patients with newly diagnosed T2DM, and HOMA-IR of the subjects was calculated using the HOMA model.</p><p><b>RESULTS</b>The diabetic patients had significantly elevated levels of serum APPL1 compared with the control subjects (85.71∓27.39 vs 64.52∓16.28 pg/ml, P<0.01), with also significantly increased BMI, WHR, SBP, FINS, LgHOMA-IR (P<0.01) and LDL-C (P<0.05) but lowered HDL-C (P<0.01). Fasting serum APPL1 levels were positively correlated with FPG, FINS, and HOMA-IR (r=0.215, 0.297, 0.334, P=0.014, 0.006, 0.002, respectively). In multiple linear regression analysis with APPL1 as the dependent variable, HOMA-IR (β=0.329, P=0.002) was included in the equation.</p><p><b>CONCLUSION</b>Patients with newly diagnosed T2DM have elevated serum APPL1 levels, suggesting the involvement of APPL1 in the development of T2DM.</p>
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Sang
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Glycémie
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Insulinorésistance
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Études cas-témoins
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Protéines adaptatrices de la transduction du signal
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Diabète de type 2
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Diagnostic
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Hyperglycémie provoquée
Type d'étude:
Diagnostic_studies
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Observational_studies
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Prognostic_studies
Limites du sujet:
Adult
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Female
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Humans
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Male
langue:
Zh
Texte intégral:
Journal of Southern Medical University
Année:
2012
Type:
Article