Prognostic value of the number of lymph nodes retrieved after selective neck dissection in hypopharyngeal squamous carcinoma / 中华耳鼻咽喉头颈外科杂志
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
;
(12): 148-153, 2013.
Article
Dans Chinois
| WPRIM
| ID: wpr-315791
ABSTRACT
<p><b>OBJECTIVE</b>To discuss the influence of the number of lymph nodes retrieved after selective neck dissection on the prognosis of hypopharyngeal squamous carcinoma.</p><p><b>METHODS</b>A retrospective review was performed on 96 patients with hypopharyngeal squamous carcinoma between January 1995 and December 2009, and all cases were accepted initial treatment for selective neck dissection. t test was used for analysis of normally distributed and Mann-Whitney U test for non-normally distributed continuous data in two groups. Comparisons were made by χ(2) analysis for categorical variables. Overall survival, disease-free survival and neck-control rate were calculated by the Kaplan-Meier method.</p><p><b>RESULTS</b>The mean number of lymph nodes retrieved in all patients with hypopharyngeal squamous carcinoma was 19.0 ± 11.3. Preoperative radiotherapy significantly decreased the number of retrieved lymph nodes and positive lymph nodes (t = -4.45, P < 0.001 and U = 568, P < 0.001, respectively). The number of nodes retrieved ≤ 15 was associated with 3-year overall survival of 37.7% compared with 71.3% in those with nodes retrieved > 15 by using Kaplan-Meier analysis (χ(2) = 8.214, P < 0.01). 3-year disease-free survival rates were 34.8% in those with ≤ 15 nodes and 61.7% in patients with > 15 nodes (χ(2) = 7.345, P < 0.01). The 3-year neck-control rates were 97.4% and 76.7% (> 15 nodes vs. ≤ 15 nodes;χ(2) = 5.539, P < 0.05), respectively. After adjusting for the effect of T stage and N stage on multivariate analysis, the number of nodes retrieved > 15 was an independent prognostic factor in patients undergoing selective neck dissection for hypopharyngeal squamous carcinoma (P < 0.05).</p><p><b>CONCLUSIONS</b>The number of lymph nodes retrieved is a valuable prognostic factor in patients received selective neck dissection for hypopharyngeal squamous carcinoma. These results suggest that at least 15 nodes should be examined in this setting.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Anatomopathologie
/
Pronostic
/
Évidement ganglionnaire cervical
/
Carcinome épidermoïde
/
Tumeurs de l'hypopharynx
/
Études rétrospectives
/
Diagnostic
/
Tumeurs de la tête et du cou
/
Noeuds lymphatiques
/
Métastase lymphatique
Type d'étude:
Etude diagnostique
/
Étude observationnelle
/
Étude pronostique
Limites du sujet:
Adulte
/
Adulte très âgé
/
Femelle
/
Humains
/
Mâle
langue:
Chinois
Texte intégral:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
Année:
2013
Type:
Article
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