Chemical constituents from roots of Platycodon grandiflorum / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study the chemical constituents from roots of Platycodon grandiflorum.</p><p><b>METHOD</b>Column chromatography (silica gel, macroporous resin, sephadex LH - 20 and the preparative RP - HPLC were used to isolate the constituents. Their structures were elucidated by physical and spectral data.</p><p><b>RESULT</b>Eight compounds were isolated and identified as tangeritin (1), 3-O-beta-D-glucopyranosylplatycodigenin methyl ester (2), 3-O-beta-D-glucopyranosylplaticogenic acid A lactone (3), 3-O-beta-D-glucopyranosylplatycodigenin (4), deapio-platyconic acid A lactone (5), deapio-platycodin-D (6), platycoside-G1 (7) and platycoside-E (8).</p><p><b>CONCLUSION</b>Compounds 1,3 and 5 were isolated from this plant for the first time.</p>