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Expression of growth hormone secretagogue receptor type 1a in visceral vagal and spinal afferent pathways / 生理学报
Acta Physiologica Sinica ; (6): 149-155, 2008.
Article Dans Chinois | WPRIM | ID: wpr-316748
ABSTRACT
In this study, the expressions of growth hormone secretagogue receptor type 1a (GHS-R1a) in the rat dorsal root ganglion (DRG) and nodose ganglion (NG) were investigated by using immunohistochemistry and in situ hybridization. The results clearly showed the presence of GHS-R1a mRNA and GHS-R1a-positive neurons in the rat DRG and NG. GHS-R1a was also co-localized with calcitonin gene-related peptide (CGRP) in some DRG and NG neurons, indicating the existence of subpopulations of the visceral afferents. The extrinsic primary afferent visceroceptive DRG and NG neurons from the stomach were identified by retrograde tracing fluorogold and stained for GHS-R1a and CGRP. Some neurons both positive for CGRP and GHS-Rla were labled by fluorogold. Our results not only demonstrate the expression of GHS-R1a in the vagal afferents but also provide the first and direct morphological evidence for its presence in the spinal visceral afferents, and gherin might have a modulatory role in the visceral afferent signaling.
Sujets)
Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Estomac / Immunohistochimie / Voies afférentes / Peptide relié au gène de la calcitonine / Biologie cellulaire / Récepteurs à la ghréline / Ganglions sensitifs des nerfs spinaux / Métabolisme / Neurones afférents / Ganglion inférieur du nerf vague Limites du sujet: Animaux langue: Chinois Texte intégral: Acta Physiologica Sinica Année: 2008 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Estomac / Immunohistochimie / Voies afférentes / Peptide relié au gène de la calcitonine / Biologie cellulaire / Récepteurs à la ghréline / Ganglions sensitifs des nerfs spinaux / Métabolisme / Neurones afférents / Ganglion inférieur du nerf vague Limites du sujet: Animaux langue: Chinois Texte intégral: Acta Physiologica Sinica Année: 2008 Type: Article