Role of hypoxia-induced VEGF in blood-spinal cord barrier disruption in chronic spinal cord injury / 中华创伤杂志(英文版)
Chinese Journal of Traumatology
;
(6): 293-295, 2015.
Article
Dans Anglais
| WPRIM
| ID: wpr-316798
ABSTRACT
Chronic spinal cord lesions (CSCL) which result in irreversible neurologic deficits remain one of the most devastating clinical problems. Its pathophysiological mechanism has not been fully clarified. As a crucial factor in the outcomes following traumatic spinal cord injury (SCI), the blood-spinal cord barrier (BSCB) disruption is considered as an important pathogenic factor contributing to the neurologic impairment in SCI. Vascular endothelial growth factor (VEGF) is a multirole element in the spinal cord vascular event. On one hand, VEGF administrations can result in rise of BSCB permeability in acute or sub-acute periods and even last for chronic process. On the other hand, VEGF is regarded to be correlated with angiogenesis, neurogenesis and improvement of locomotor ability. Hypoxia inducible factor-1 (HIF-1) is a primary regulator of VEGF during hypoxic conditions. Therefore, hypoxia-mediated up-regulation of VEGF may play multiple roles in the BSCB disruption and react on functional restoration of CSCL. The purpose of this article is to further explore the relationship among HIF-1, hypoxia-mediated VEGF and BSCB dysfunction, and investigate the roles of these elements on CSCL.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Physiologie
/
Moelle spinale
/
Traumatismes de la moelle épinière
/
Maladie chronique
/
Néovascularisation physiologique
/
Facteur de croissance endothéliale vasculaire de type A
/
Facteur-1 induit par l'hypoxie
/
Neurogenèse
Limites du sujet:
Animaux
/
Humains
langue:
Anglais
Texte intégral:
Chinese Journal of Traumatology
Année:
2015
Type:
Article
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