The therapeutic effect of high-dose esomeprazole on stress ulcer bleeding in trauma patients / 中华创伤杂志(英文版)
Chinese Journal of Traumatology
;
(6): 41-43, 2015.
Article
Dans Anglais
| WPRIM
| ID: wpr-316855
ABSTRACT
<p><b>PURPOSE</b>To compare the therapeutic effects of different doses of intravenous esomeprazole on treating trauma patients with stress ulcer bleeding.</p><p><b>METHODS</b>A total of 102 trauma patients with stress ulcer bleeding were randomly divided into 2 groups 52 patients were assigned to the high-dose group who received 80 mg intravenous esomeprazole, and then 8 mg/h continuous infusion for 3 days; 50 patients were assigned to the conventional dose group who received 40 mg intravenous esomeprazole sodium once every 12 h for 72 h.</p><p><b>RESULTS</b>Compared with the conventional dose group, the total efficiency of the high-dose group and conventional dose group was 98.08% and 86.00%, respectively (p < 0.05), the hemostatic time was 22.10 h ± 5.18 h and 28.27 h ± 5.96 h, respectively (p < 0.05).</p><p><b>CONCLUSION</b>Both doses of intravenous esomeprazole have good hemostatic effects on stress ulcer bleeding in trauma patients. The high-dose esomeprazole is better for hemostasis.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Ulcère gastrique
/
Stress psychologique
/
Plaies et blessures
/
Hémorragie de l'ulcère gastroduodénal
/
Utilisations thérapeutiques
/
Relation dose-effet des médicaments
/
Traitement médicamenteux
/
Ésoméprazole
/
Antiulcéreux
Limites du sujet:
Adolescent
/
Adulte
/
Adulte très âgé
/
Femelle
/
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Chinese Journal of Traumatology
Année:
2015
Type:
Article
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