Influence of adefovir dipivoxil on HBV specific CTL in patients with chronic hepatitis B / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology
;
(6): 362-363, 2010.
Article
Dans Chinois
| WPRIM
| ID: wpr-316898
ABSTRACT
<p><b>OBJECTIVE</b>To explore the influence of adefovir dipivoxil on HBV specific CTL in patients with chronic hepatitis B (CHB).</p><p><b>METHODS</b>10 mg adefovir dipivoxil (Zhengda Tianjing Pharmaceutical Company) was used for CHB patients with positive HBV DNA (HBV DNA > or = 1 x 10(4) copies/ml), ALT > 2 x upper limit of normal value (ULN) and positive human leucocyte antigen (HLA)-A2, orally, once a day for 3 months. Real time fluorescent quantitative PCR was used to determine HBV DNA and flowcytometer was used to determine HBV specific CTL.</p><p><b>RESULTS</b>After treatment with adefovir dipivoxil for 3 months, HBV specific CTL (0.52 +/- 0.11)% was higher than that before treatment (0.34 +/- 0.14)%, t = 6.78 P < 0.01, HBV DNA of 28 cases turned to negative (<1 x 10(3) copies/ml) (62.22%). HBV DNA of 17 cases failed to turn negative 3 months after treatment, but their HBV DNA level was lower [(4. 18 +/- 0.4) log 10 copies/ml] than that before treatment [(6.23 +/- 0.73) log 10 copies/ml], t = 9.99, P < 0.01.</p><p><b>CONCLUSION</b>Adefovir dipivoxil can improve HBV specific cellular immunity in patients CHB.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Antiviraux
/
Calendrier d'administration des médicaments
/
Adénine
/
Lymphocytes T cytotoxiques
/
Hépatite B chronique
/
Traitement médicamenteux
/
Allergie et immunologie
/
Phosphonates
Limites du sujet:
Adulte
/
Femelle
/
Humains
/
Mâle
langue:
Chinois
Texte intégral:
Chinese Journal of Experimental and Clinical Virology
Année:
2010
Type:
Article
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