Molecular epidemiology investigation of rabies virus nucleoprotein genes in China / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology
;
(6): 82-84, 2010.
Article
Dans Chinois
| WPRIM
| ID: wpr-316959
ABSTRACT
<p><b>OBJECTIVE</b>To study the relationship between the distribution of rabies virus and genetic variation, the genetic characterization and variation of rabies virus strains in China were analyzed.</p><p><b>METHODS</b>The downstream 720 nucleotides of Nucleoprotein (N) gene coding region of the rabies specimens from different areas and host animals were sequenced, and then homology and phylogenesis were analyzed.</p><p><b>RESULTS</b>Nucleotide similarities of 34 N gene sequences were 87.5%-100%, and the deduced amino acid similarities were 93.3%-99.6%. Most of the nucleotide variations were synonymous mutations.</p><p><b>CONCLUSION</b>The 34 rabies specimens all belong to genotype I and are of regional characteristic. The rabies viruses in high-incidence areas in China are of various origins and present the transmission tendency from high-incidence areas to surrounding regions. There may be cross-infection and mutual spread of rabies virus between wildlife and domestic animals as well as native and foreign animals.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Phylogenèse
/
Rage (maladie)
/
Virus de la rage
/
Virologie
/
ARN viral
/
Chine
/
Classification
/
Épidémiologie moléculaire
/
Génétique
/
Nucléoprotéines
Type d'étude:
Étude de dépistage
Limites du sujet:
Animaux
/
Humains
Pays comme sujet:
Asie
langue:
Chinois
Texte intégral:
Chinese Journal of Experimental and Clinical Virology
Année:
2010
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS