A novel treatment for weight reduction by the recombinant "Pichia pastoris" yeast expressing the hybrid protein of "irisin-furin-transferrin" / 中西医结合学报
Journal of Integrative Medicine
; (12): 1-4, 2016.
Article
Dans En
| WPRIM
| ID: wpr-317055
Responsable en Bibliothèque :
WPRO
ABSTRACT
Obesity is a major health problem across the world, but there are few ways to effectively treat or manage it in the long term. Researchers are searching for more convenient, cost-effective and noninvasive therapies for overweight and obese people. Recent studies have illustrated that the microbiome of the body's different organs can be used as a vehicle for in-situ gene therapy. We suggest that the recombinant form of "Pichia pastoris" yeast expressing the hybrid protein of "irisin-furin-transferrin" under the control of the enolase 1 promoter is a new nutraceutical strategy to absorb fewer calories from intestinal nutrients, and induce a higher metabolic rate to expend more calories, similar to that from engaging in physical activity. By comparison, this method can be a long-term, noninvasive treatment and can be used for obese patients who have movement limitations.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Pichia
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Thérapeutique
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Protéines de fusion recombinantes
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Transferrine
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Thérapie génétique
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Perte de poids
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Fibronectines
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Furine
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Génétique
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Obésité
Limites du sujet:
Humans
langue:
En
Texte intégral:
Journal of Integrative Medicine
Année:
2016
Type:
Article