Orthogonal experiments for optimizing the formulation and preparation conditions of temozolomide solid lipid nanoparticles / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 1141-1145, 2008.
Article
Dans Chinois
| WPRIM
| ID: wpr-318197
ABSTRACT
TMZ-SLN were prepared by emulsification-low temperature solidification method with stearic acid. The formulation and the preparation conditions were optimized by orthogonal experiments using entrapment efficiency as the evaluation index. The morphology was detected by transmission electron microscope. The Zeta potentials and the particle size distribution were evaluated by Laser Doppler Anemometry. The entrapment efficiencies and the drug release characteristics in vitro were assessed. The result showed that TMZ-SLN were concinnous and spherical in shape. The mean diameter (d(av) ) was 65.0 +/- 6.2 nm and the Zeta potential was -37.2 mV. The average entrapment efficiency was 58.9% +/- 1.21 %. The drug release behavior in vitro conformed to Higuchi Equation. The formation of a new material phase was testified by analysis of differential scanning calorimetry.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Taille de particule
/
Acides stéariques
/
Vecteurs de médicaments
/
Chimie
/
Antinéoplasiques alcoylants
/
Dacarbazine
/
Nanoparticules
/
Lipides
langue:
Chinois
Texte intégral:
Journal of Biomedical Engineering
Année:
2008
Type:
Article
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