Repair of peripheral nerve gap with the use of tissue engineering scaffold complex / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 688-691, 2005.
Article
Dans Chinois
| WPRIM
| ID: wpr-318836
ABSTRACT
<p><b>OBJECTIVE</b>To study the feasibility to repair the peripheral nerve gap with tissue engineering scaffold complex that is composed of medical biodegradable material agarose hydrogel and nerve growth factor (NGF).</p><p><b>METHODS</b>Chitosan tube containing agarose hydrogel and NGF was transplanted to bridge a 10 mm gap of injured sciatic nerve in rat. Chitosan duct without agarose hydrogel and NGF was used as negative control, while autograft nerve as positive control. Sixteen weeks after operation, the regeneration of nerve fiber was observed with morphological and immunohistochemistrical methods.</p><p><b>RESULT</b>The number and diameter of regenerating nerve fibers bridged by the scaffold complex of agarose hydrogel and NGF were better than negative control group (P < 0.01) and reached the level of autograft nerve group.</p><p><b>CONCLUSIONS</b>The new type of tissue engineering scaffold complex of agarose hydrogel and NGF may provide a microenvironment, as well as autograft nerve, to promote nerve regeneration. This technique may benefit patients with nerve injury in the future.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Nerfs périphériques
/
Pharmacologie
/
Agarose
/
Chirurgie générale
/
Matériaux biocompatibles
/
Endoprothèses
/
Études de faisabilité
/
Rat Sprague-Dawley
/
Implantation de prothèse
/
Type d'étude:
Étude pronostique
Limites du sujet:
Animaux
langue:
Chinois
Texte intégral:
Acta Academiae Medicinae Sinicae
Année:
2005
Type:
Article
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