Advances in molecular genetics of schizophrenia / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 401-407, 2005.
Article
Dans Chinois
| WPRIM
| ID: wpr-318897
ABSTRACT
Schizophrenia (MIM 181500) is a complex disorder affecting approximately 1% of the population worldwide. Epidemiologic evidences, together with recent linkage and association studies, have clearly demonstrated the high heritability of schizophrenia (up to 80%). Uncovering the genetic mechanism of schizophrenia has became one of the greatest challenges for both psychiatry and genetics. In recent years, remarkable advances in the genetics of this disorder has been achieved with the rapid growth of human genome information and experiment technologies. Several candidate genes within some of the best-supported linkage regions have been reported and, more importantly, replicated. Moreover, these genes present a significant connection in the signaling pathways implicated in the development of schizophrenia, especially NMDA receptor-mediated glutamate transmission. In this review, we summarize the recent advances in the genetics of schizophrenia, focusing particularly on linkage disequilibrium analysis and the latest understanding of the neurobiology of the disorder.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Schizophrénie
/
Acyltransferases
/
Protéines de transport
/
Récepteurs du N-méthyl-D-aspartate
/
Neuréguline-1
/
Protéines associées à la dystrophine
/
Dysbindine
/
Génétique
/
Protéines membranaires
/
Protéines de tissu nerveux
Limites du sujet:
Humains
langue:
Chinois
Texte intégral:
Acta Academiae Medicinae Sinicae
Année:
2005
Type:
Article
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