Intrarenal artery injection of L-arginine inhibits spontaneous activity of renal afferent nerve fibers / 生理学报
Acta Physiologica Sinica
;
(6): 225-231, 2003.
Article
Dans Anglais
| WPRIM
| ID: wpr-318912
ABSTRACT
The purpose of this study was to determine the effect of intrarenal artery injection of L-arginine on multi- and single-unit spontaneous discharges of renal afferent nerve fibers in anesthetized rabbits. The results obtained are as follows (1) intrarenal artery injection of L-arginine (0.05, 0.24, and 0.48 mmol/kg) decreased the renal afferent nerve activity (ARNA) in a dose-dependent manner with arterial pressure unchanged; (2) pretreatment with a nitric oxide synthase inhibitor L-NAME (N6-nitro-L-arginine methylester, 0.11 mmol/kg), completely abolished the effect of L-arginine; and (3) intrarenal artery injection of a nitric oxide donor SIN-1 (3-morpholinosydnonimine, 3.75 micromol/kg) also resulted in an inhibition of ARNA. The results suggest that intrarenal artery injection of NO precursor (L-arginine) and donor (SIN-1) can inhibit ARNA in anesthetized rabbits.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Pharmacologie
/
Arginine
/
Physiologie
/
Artère rénale
/
Fibres afférentes viscérales
/
Dépression chimique
/
Phénomènes électrophysiologiques
/
Injections artérielles
/
Rein
/
Neurofibres
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Acta Physiologica Sinica
Année:
2003
Type:
Article
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