The roles of carbon monoxide on hypoxic pulmonary vasoconstriction / 中国应用生理学杂志
Chinese Journal of Applied Physiology
;
(6): 261-263, 2002.
Article
Dans Chinois
| WPRIM
| ID: wpr-319313
ABSTRACT
<p><b>AIM AND METHODS</b>To study the roles of carbon monoxide on hypoxic pulmonary vasoconstriction (HPV) by investigating the effects of exogenous carbon monoxide and heme oxygenase inhibitor ZnPPIX on hypoxic vasoconstriction reaction of isolated rat pulmonary arterial rings (PAR).</p><p><b>RESULTS</b>Hypoxia caused constriction in PAR preconstricted by PE. Both ZnPPIX and carbon monoxide inhibited hypoxic pulmonary constriction significantly by increasing the cGMP level after hypoxia.</p><p><b>CONCLUSION</b>ZnPPIX and exogenous carbon monoxide can inhibit HPV. The reduction of cGMP induced by the decreased of CO may be one of reasons of HPV.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Physiologie
/
Artère pulmonaire
/
Vasoconstriction
/
Techniques in vitro
/
Monoxyde de carbone
/
Rat Wistar
/
Hypoxie
Limites du sujet:
Animaux
langue:
Chinois
Texte intégral:
Chinese Journal of Applied Physiology
Année:
2002
Type:
Article
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