Expression of aquaporin-4 protein in the brain of preeclampsia model rats / 南方医科大学学报
Journal of Southern Medical University
; (12): 1329-1331, 2013.
Article
Dans Zh
| WPRIM
| ID: wpr-319418
Responsable en Bibliothèque :
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the expression of aquaporin-4 (AQP4) protein in preeclampsia(PE) model rats.</p><p><b>METHODS</b>Adult SD rats were divided into PE model group (n=7) induced by endotoxin, normal pregnancy group (n=6) and non-pregnancy group (n=12) treated with an equal volume of saline. AQP4 protein expression in the brain of the rats was detected with immunohistochemical staining and Western blotting.</p><p><b>RESULTS</b>The blood pressure in PE model rats (135∓9 mmHg) was significantly higher than that in normal pregnancy rats (116∓8 mmHg) and non-pregnancy rats (112∓6 mmHg) (P<0.02). The rats in PE model group showed obvious proteinuria compared with the other two groups (3.8∓0.5 vs 2.6∓0.6 and 2.3∓0.4, P<0.05). Immunohistochemistry showed that AQP4 protein was localized primarily around the brain parenchymal blood vessels. Western analysis revealed a significantly elevated AQP4 protein expression in PE model group (39.6∓4.9) compared with that in normal pregnancy group (26.5∓4.3) and non-pregnancy group (9.7∓2.1) (P<0.01).</p><p><b>CONCLUSION</b>The up-regulation of AQP4 protein around the intraparenchymal blood vessels of the brain may play a role in the development of eclampsia.</p>
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Pré-éclampsie
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Pression sanguine
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Rat Sprague-Dawley
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Modèles animaux de maladie humaine
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Aquaporine-4
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Génétique
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Hippocampe
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Métabolisme
Limites du sujet:
Animals
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Pregnancy
langue:
Zh
Texte intégral:
Journal of Southern Medical University
Année:
2013
Type:
Article